Reduced Ca Flux via Ryanodine Receptor Cluster Size or Unitary Current can both Promote Long-Lasting Ca Sparks
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چکیده
منابع مشابه
Ryanodine Receptor Current Amplitude Controls Ca Sparks in Cardiac Muscle
Rationale: In cardiac muscle, Ca -induced Ca release (CICR) from the sarcoplasmic reticulum (SR) is mediated by ryanodine receptor (RyR) Ca release channels. The inherent positive feedback of CICR is normally well-controlled. Understanding this control mechanism is a priority because its malfunction has life-threatening consequences. Objective: We show that CICR local control is governed by SR ...
متن کاملMolecular Medicine Ryanodine Receptor Current Amplitude Controls Ca Sparks in Cardiac Muscle
Rationale: In cardiac muscle, Ca -induced Ca release (CICR) from the sarcoplasmic reticulum (SR) is mediated by ryanodine receptor (RyR) Ca release channels. The inherent positive feedback of CICR is normally well-controlled. Understanding this control mechanism is a priority because its malfunction has life-threatening consequences. Objective: We show that CICR local control is governed by SR ...
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The multifunctional Ca /calmodulin-dependent protein kinase II C (CaMKII C) is found in the macromolecular complex of type 2 ryanodine receptor (RyR2) Ca release channels in the heart. However, the functional role of CaMKII-dependent phosphorylation of RyR2 is highly controversial. To address this issue, we expressed wild-type, constitutively active, or dominant-negative CaMKII C via adenoviral...
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The kinetic behavior of Ca(2+) sparks in knockout mice lacking a specific ryanodine receptor (RyR) isoform should provide molecular information on function and assembly of clusters of RyRs. We examined resting Ca(2+) sparks in RyR type 3-null intercostal myotubes from embryonic day 18 (E18) mice and compared them to Ca(2+) sparks in wild-type (wt) mice of the same age and to Ca(2+) sparks in fa...
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Fellner SK, Arendshorst WJ. Voltage-gated Ca entry and ryanodine receptor Ca -induced Ca release in preglomerular arterioles. Am J Physiol Renal Physiol 292: F1568–F1572, 2007. First published December 26, 2006; doi:10.1152/ajprenal.00459.2006.—We have previously shown that in afferent arterioles, angiotensin II (ANG II) involves activation of the inositol trisphosphate receptor (IP3R), activat...
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ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2015
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2014.11.1448